CO127 Systematic Literature Review (SRL) of Comparative Safety and Effectiveness of Hormonal LARCs

To review published evidence on Comparative Effectiveness and Humanistic Burden of Hormonal LARCs Levonorgestrel-IUD (LNG-IUD) Etonogestrel Subdermal Implant (ESI). A systematic literature search was performed using MEDLINE via PubMed, LILACS CENTRAL. strategy formulated studies up to 2021 were included. Two reviewers independently selected the studies, summarized data, assessed risk bias. Critical evaluation included appropriate tools. Systematic reviews clinical trials in women childbearing age who received hormone functioning eligible for inclusion. Summary effect measures present mean differences (MD), homogeneity (I2) odds ratio (OR). In a preliminary assessment eligibility (title abstract), 793 excluded. furthermore detailed analysis (studies full), we excluded 102 following reasons: study design incorrect population. end, 3 met our inclusion criteria data synthesis. terms efficacy outcomes, ESI more effective compared LNG-IUD (0.5% 0.9% LNG 0.0% ESI). young women, implant showed superior pregnancy rate IUD (RR=1.44). Evidence continuation comparison between IMP-ETN are still controversial (I2>86). 6-week postpartum period, relevant rates (70% 100%) at 3, 6, 12 months evidenced favor ESI. Meta-analysis comparing AEs IUDs vs but did not show statistically significant safety. The safer LNG-IUD. There limitations current evidence, mainly due device based approach.